How Molecular Size Influences the Efficacy of Skincare Ingredients
- Cloud Vitamin Cream
- Nov 18
- 2 min read
The majority of skincare brands incorporate active ingredients that are too large for optimal skin absorption. The implication is that these creams primarily rest on the surface of the skin,

functioning as costly moisturizers. While they may provide a pleasant sensation, they are ineffective in delivering results.
Understanding how molecular size influences vitamin absorption can change the way you think about your skincare routine. Smaller molecules in Topical Creams ensures the Active Ingredients drive through the Dermal layers to get where they need to be to deliver results you can see and feel. Let’s briefly explore why dermatologist-developed formulations with carefully selected molecular sizes make all the difference in formulating creams that actually work.
The Science of Small Molecules
When it comes to skincare, the size of the molecules (vitamins) in your product matters. Smaller molecules are required for full skin penetration, allowing active ingredients to reach deeper layers where they can deliver powerful results. This means your skin receives the full benefit of every ingredient.
These molecules need to be small because the skin's outermost layer, the stratum corneum, functions as a formidable and selective barrier with very small gaps. The stratum corneum is composed of dead skin cells (corneocytes) held together by a lipid matrix, often described as a "brick and mortar" structure. This compact, brick-like arrangement creates a tight barrier that regulates what can enter the body and what stays out.
Molecules generally need to be under 500 Daltons in molecular weight to pass through this barrier with ease. Many effective vitamin molecules like certain forms of Vitamin C, E, and A are small enough to meet this criterion. Larger molecules, such as collagen, are too big to penetrate deeply and only provide surface-level benefits. As you can see, understanding which molecules to use and what size is paramount to formulating effective Topical applications.
Revolutionizing Skincare
Cloud Vitamin Cream's Formulas are the result of four decades of dermatological expertise, the latest Science on Skin, and hundreds of patient trials. Cloud's formulations focus on pure vitamins that have proven to be 100% absorbed in 10 minutes. Additionally, Cloud Vitamin Cream uses a penetrative base to ensure there are no additional absorption inhibitors.
There are many factors that impact the pathways of absorption of Topical Vitamin Creams, and the size of the molecules used is way up top. Try to use products created by Dermatologists with the experience and knowledge it takes to formulate absorbable Creams that will protect, restore, and enhance the health of your skin.



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